Preventive Effect of Total Saponins of Panax Notoginseng on Experimental Atherosclerosis in Rabbits
- VernacularTitle:三七总皂苷对家兔实验性动脉粥样硬化的预防作用
- Author:
Xuefeng HE
;
Xiaohui LI
;
Shuhui LI
;
Cuiyao HE
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Total Saponins of Panax Notoginseng;
Preventive effect
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect of PNS on experimental atherosclerosis in rabbits, including the serum levels of TG, TC, LDL-C, level of MDA, activity of SOD and plaque area. METHODS: White Japanese rabbits were divided into normal control group, AS model group, low dose PNS group and high dose PNS group. Administration was for 12 consecutive weeks. The serum levels of TG, TC, LDL-C, MDA and activity of SOD were determined before experiment and at the end of the 12th week, respectively. RESULTS: The serum levels of TG, TC and LDL-C in AS model group were significantly higher than that in control group ( P
