Effects of tamoxifen on volume-activated Cl-currents of nasopharyngeal carcinoma cells at different stages of the cell cycle
- VernacularTitle:他莫昔芬对不同生长周期鼻咽癌细胞容积激活性电流的作用
- Author:
Haibing LUO
;
Liwei WANG
;
Jianwen MAO
;
Chenggang JIAO
;
Aihui FAN
;
Sihuai NIE
;
Pan LI
;
Lixin CHEN
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Chloride channels;
Tamoxifen;
Cell cycle
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
gluconate in both G1 phase and S phase cells.The permeability of G1 phase cells to I-was higher than that in S phase cells,but to gluconate was lower than that in S phase cells.CONCLUSIONS: The density of the volume-activated Cl-current,the anion permeability of the channel and the sensitivity of the current to tamoxifen were different between the CNE-2Z cells in G1 phase and those in S phase.The results suggest that the expression of tamoxifen-sensitive,volume-activated chloride channels is differentiated at different stages of the cell cycle.
