Effects of bilirubin on oxygen free radicals and caspase-3 in acute lung injury rats
- VernacularTitle:胆红素对大鼠急性肺损伤形成过程中氧自由基以及caspase-3表达的影响
- Author:
Wenxia REN
;
Qingmei GONG
;
Ying ZHAO
;
Jianqiang LI
;
Zhuola LIU
- Publication Type:Journal Article
- Keywords:
Bilirubin;
Lung injury;
Caspase 3;
Reactive oxygen species;
Apoptosis
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the mechanisms by which bilirubin inhibits acute lung injury(ALI).METHODS: 30 female Wistar rats were divided into normal group,ALI group and bilirubin treatment group.ALI was induced by intravenous injection of LPS.The contents of OH-,H2O2 and O——?-2 in the lung as well as the expression of caspase-3 in the lungs were investigated.RESULTS:(1) The contents of OH-,H2O2 and O——?-2 in the lung homogenate and the expression of caspase-3 in the lungs in ALI group increased compared with those in normal group(P
