Effects of cholecystokinin octapeptide on expression of IL-1?,IL-6,IL-4 and IL-10 in lipopolysaccharide-attacked mice
- VernacularTitle:CCK-8对LPS攻击小鼠IL-1?、IL-6、IL-4、IL-10表达的影响
- Author:
Zhiyu NI
;
Bin CONG
;
Shujin LI
;
Chunling MA
;
Yuxian YAN
;
Jinrong XU
;
Guozhong ZHANG
- Publication Type:Journal Article
- Keywords:
Cholecystokinin;
Lipopolysaccharides;
Interleukins
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the effects of cholecystokinin octapeptide(CCK-8) on the expression of proinflammatory cytokines IL-1?,IL-6 and anti-inflammatory cytokines IL-10,IL-4 in LPS-attacked mice.METHODS: Kunming mice were randomly assigned and injected intraperitoneally with LPS alone or/and CCK-8 at different time points.The expression of IL-1?,IL-6,IL-10 and IL-4 in the serum and lung tissues were assayed by ELISA and RT-PCR.RESULTS: The expression of IL-1?,IL-6,IL-10 and IL-4 were upregulated in LPS-attacked mice.Pre-treatment of CCK-8 decreased both IL-1? and IL-6 expression and augmented IL-10 and IL-4 expression in LPS-attacked mice.CONCLUSIONS: CCK-8 exerts an anti-inflammatory effect by inhibiting the expression of IL-1?,IL-6 and increasing the expression of IL-10,IL-4 in LPS-attacked mice,which could alleviate the inflammatory response in lung tissue.
