A comparative study of targeting drug magnetic nanoparticles and other chemotherapy drugs on human cholangiocarcinoma xenografts

VernacularTitle:磁靶纳米化疗药物治疗胆管癌移植瘤的对比研究
Author: Tao TANG ; Jianwei ZHENG ; Hong LI ; Baolai XIAO ; Bo CHEN ; Gao LI ; Shuai XU ; Shengquan ZHOU ; Xing AI ; Xi LI
Publication Type:Journal Article
Keywords: Bile Duct Neoplasms/drug ther; Neoplasms,Experimental; Neoplasm Transplantation; Targeting Drug Magntic Nanopaticles/ther use
From: Chinese Journal of General Surgery 1993;0(02):-
CountryChina
Language:Chinese
Abstract: Objective To study the effect of magnetic nanoparticles on human cholangiocarcinoma xenograft in nude mice, and compared with otherchemotherapy drugs Methods We established human cholangiocarcinoma xenograft in nude mice with QBC939 cell line.The nude mice were devided into 4 groups randomly.Saline,5-FU, Gemcitabine and magnetic nanoparticles were given to nude mice through tail vein on 20d after implanting QBC939 cell line. Calculations were done at different time after treatment in order to compare tumor volume,inhibition ratio of tumor and tumor growth curve of each group. The nude mice were killed on 35d after treatment to harvest tissue for electron microscopic examination to observe ultra-structural changes. Results The tumor volume of control, 5-FU, magnetic nanoparticles and Gemcitabine groups was (2256.1?267.1) mm3, (2096.5?237.9)mm3,(1392.2?189)mm3, and (1534.9?115 )mm3 respectively.The last two groups have significant difference compared to the first two groups(P