Formula Optimization of Aspirin Chitosan-Sodium Alginate Microcapsules and Drug Releasing Mechanism Study
- VernacularTitle:阿司匹林壳聚糖-海藻酸钠微囊处方优化与释药机制研究
- Author:
Yanqing ZHANG
;
Mingchun ZHANG
;
Junbo XIE
;
Wuqin QI
;
Shuzhen HAN
- Publication Type:Journal Article
- Keywords:
Aspirin;
Alginic acid;
Chitosan;
Microcapsules;
Formula;
Mechanism of drug release
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare aspirin chitosan-sodium alginate microcapsules(ACSPM)and to investigate its optimal formula and releasing mechanism.METHODS:The formula of ACSPM was optimized by the orthogonal design with entrapment ratio as index,and then ACSPM was prepared,with its release rate determined as well.The releasing mechanism of aspirin from the microcapsules was established by equation fitting of releasing kinetic model.RESULTS:The prepared microcapsules were uniform in size and contents.The optimized formula was as follows:the concentration of sodium polymannuronate and chitosan were 3.0% and 1.0%,respectively,and the proportion of polymannuronate to aspirin was 1∶ 4.The in vitro drug release was in line with both Higuchi equation and Peppas equation.CONCLUSION:This preparation technology was simple and the drug releasing mechanism of the preparation was chiefly characterized by drug diffusion including bulk erosion non-Fickian process.
