Age related changes in 5-methylcytosine content in human peripheral leukocytes by HPLC
- VernacularTitle:HPLC法检测人外周血5-~mC含量及其与年龄相关性研究
- Author:
Hui YIN
;
Daixin HUANG
;
Xiandun ZHAI
- Publication Type:Journal Article
- Keywords:
Forensic biological evidence;
5-methylcytosine;
HPLC;
Age
- From:
Chinese Journal of Forensic Medicine
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate age-dependent variation of 5-methylcytosine (5-mC) content in human peripheral leukocytes.Methods 94 healthy individuals (50 males and 44 females) of ages varying from 4 to 87 years were dividied into six groups by age: age under 20 years, age between 20 to 30 years, age between 30 to 40 years, age between 40 to 50 years, age between 50 to 60 years and age beyond 60 years. Their 5-mC content in human peripheral leukocytes were analyzed by HPLC.Results The 5-mC content of age between 50 to 60 years (mean age 54.7) and age beyond 60 years (mean age 71.7) are statistically not significant, but statistically highly significant (P
