Influence of the Detoxification and Dissipation Blood Stasis Formula Ⅱ on Hepatic Mitochondria Lipid Peroxidation in Rats with Hepatic Failure
- VernacularTitle:解毒化淤Ⅱ方中药配方颗粒剂对肝衰竭大鼠肝线粒体脂质过氧化的影响
- Author:
Dewen MAO
;
Hua QIU
;
Jing YU
;
Yinyao MA
- Publication Type:Journal Article
- Keywords:
The detoxification and dissipation blood stasis formula Ⅱ;
Fulminant hepatic failure;
Lipid peroxidation;
Hepatic mitochondria;
Traditional Chinese medicine granule
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the influence of TCM Granules of the detoxification and dissipation blood stasis formula Ⅱon fulminant hepatic mitochondrial lipid peroxidation in rats with hepatic failure.METHODS:The fulminant hepatic failure rat models were established by subcutaneous injection of thioacetamide (TAA).48 Wistar rats were randomly divided into 7 groups:blank control group,model group,low dose group,medium dose group,high dose group,the lactulose treatment group,and the "Bezoar pill for resurrection" treatment group.Intragastric administration was executed 3 d before model-making,twice per day with the interval of 12 hours.They were administered for 11times.12 hours after model establishment.MDA、SOD、CAT、GSH、NO and liver necrosis area in hepatic mitochondria were determined.RESULTS:The detoxification and dissipation blood stasis formula Ⅱcould notably reduce liver necrosis area and restrain produce of hepatic mitochondrial lipid peroxidatide MDA,retrieve the activity of SOD、CAT and increase the content of GSH,NO.Moreover it shows dose-effect relation.Compared with model group,there is statistical significance(P
