Influence of tripterygium polyglycosid (雷公藤) on airway inflammation and remodeling in rats with allergic asthma
- VernacularTitle:雷公藤对哮喘大鼠气道炎症及重塑影响的研究
- Author:
Zhenghai QU
;
Ning XIE
;
Xiaomei LIU
;
Yuqiang HUANG
;
Rongjun LIN
- Publication Type:Journal Article
- Keywords:
tripterygium polyglycosid;
asthma;
nuclear factor-?B;
matrix metalloproteinases;
eosinocyte
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of tripterygium polyglycosid(TP,雷公藤) on airway inflammation and remodeling in rats with asthma.Methods: Forty rats were randomly divided evenly into negative control group,positive control group,normal dose TP group(TPⅠ group) and small dose TP group(TPⅡgroup).The experimental model was induced by ovalbumin sensitization.Number of cells in bronchoalveolar lavage fluid(BALF) was observed by immunocytochemical staining.The expressions of nuclear factor-?B(NF-?B),matrix metalloproteinases-9(MMP-9) and tissue of inhibitor of metalloproteinases-1(TIMP-1) were detected by immunohistochemistry method.Results: Compared with the negative control group,the counts of lymphocyte,neutrophilic leukocyte,macrophage and eosinocyte in BALF were elevated significantly,positive cell percentages of NF-?B, MMP-9 and TIMP-1 in lung tissues increased greatly in positive control group,the differences being significant(all P
