Pharmacokinetics of Ferulic Acid in Serum of Healthy Male Volunteers After Oral Administration of Guanxin Ⅱ Decoction
- VernacularTitle:健康志愿者口服冠心Ⅱ号煎剂后血清中阿魏酸的药动学研究
- Author:
Hongquan GAN
;
Qibing MEI
- Publication Type:Journal Article
- Keywords:
Traditional Chinese medical compound formula;
GuanxinⅡ;
Decoction;
Ferulic acid;
Pharmacokinetics
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the concentration- time curve of ferulic acid(FA) in serum of healthy male volunteers after oral administration of Guanxin II (GXEH) and to study its pharmacokinetic parameters.METHODS: Serum FA level was determined by HPLC in healthy male volunteers after single oral administration of GXEH(4.5g?kg-1) decoction. RESULTS: No double - peak occurred in the concentration - time curve of FA.6 -fold interindividual variation was noted in maximum blood drug level.The pharmacokinetic parameters were stated as follows: Ka: (0.26?0.350) min-1; Ke: (0.013?0.004 17)min-1;t1/2Ke: (63.45?32.288)min;tmax:(24.117?14.631) min, AUC:(13 263.51?6 478.275)ng?min-1?mL-1; CL/F(s):(0.000 44?0.000 268)L?g-1?min-1.CONCLUSION:There is a significant individual FA level difference in healthy male volunteers after oral oral administration of GXEH decoction,and both the absorption and the elemination of FA are fast.
