Effects of captopril on expression of calcineurin and NF-?B p65 in the heart of hypertensive rats
- VernacularTitle:卡托普利对高血压心脏钙调蛋白磷酸酶与核因子?Bp65蛋白表达的影响
- Author:
Jinxing CHEN
;
Rutai HUI
;
Qian ZHANG
;
Yi ZHENG
;
Chunyan FU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Calcineurin;
NF-kappa B;
Captopril;
Signal transduction
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the effect of captopril on calcineurin and NF-?B p65 in the signal transduction pathway of the cardiovascular remodeling in hypertensive rats.METHODS:Using a animal model of hypertension induced by abdominal aortic banding,the rats were treated with captopril for 10 weeks.The blood pressure was observed with a tail cuff method.The heart weight and heart weight/body weight were measured.The expression of calcineurin and NF-?B p65 were studied by using immunohistochemistry.RESULTS:After treated with captopril,the blood pressure of the model rats was decreased(P
