Mutation and expression of ?-catenin gene in breast cancer
- VernacularTitle:乳腺癌中?-catenin基因突变和表达的研究
- Author:
Zhen LIU
;
Guiyou WANG
;
Dongxu CUI
;
Baolin LIU
;
Xiaobo ZHANG
;
Wenfeng MA
;
Qiang ZHANG
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms/Pathol;
?-catenin;
Gene Expression
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of ?-catenin gene in breast tumorigenesis.Methods Mutation and expression of ?-catenin gene in 42 breast cancer tissues were detected by polymerase chain reaction-single strand conformation polymorphism and immunohistochemistry.Results The rate of abnormal expression of ?-catenin in breast cancer tissuse was 59.5%(25/42).Mutation of ?-catenin gene was not detected in breast cancer tissue.Conclusions Abnormal expression of ?-catenin plays an important role in human breast tumorigenesis,but the cause of abnormal expression of ?-catenin is not mutation of ?-catenin gene.
