Expression of BRMS1 mRNA in human breast cancer and its clinical significance
- VernacularTitle:BRMS1 mRNA在乳腺癌组织中的表达及其意义
- Author:
Lubing TANG
;
Jingzhong SUN
;
Rong MA
;
Tiantian WANG
;
Haidong GAO
;
Zhigang YU
;
Jinbo FENG
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms/pathol;
Gene,BRMSI;
Gene Expression;
Breast Cancer/progno
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of BRMS1mRNA in human breast cancer tissues and their significance.Methods The expression of BRMS1mRNA was detected by reverse transcription-polymerase chain reaction(RT-PCR) in 71 breast cancer tissues and adjacent breast tissues,12 patients with benign breast tumors and 12 patients with normal breast tissue,and semi-quantitative analysis of band densities was also performed.Results The expression of BRMS1mRNA in 71 patients with breast cancer and adjacent breast tissue was 0.378?0.046 and 0.918?0.044,respectively;the expression of BRMS1mRNA in 12 patients with benign breast tumors and 12 patients with normal breast tissue was 0.908?0.047 and 0.934?0.028 respectively.BRMS1mRNA expression was significantly lower in breast cancer tissue compared to adjacent breast tissue,benign breast tumors and normal breast tissue(P0.05),but was related to axillary lymph node metastasis and clinical stage(P
