The expression of the RECK mRNA and MMP-9 mRNA in the breast cancer and fibroadenoma tissues
- VernacularTitle:乳腺癌和纤维瘤中RECK-mRNA和MMP9-mRNA的表达差异及意义
- Author:
Zhijun HUO
;
Daojin CHEN
;
Xiaorong LI
;
Lili TANG
;
Wei WU
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms/Pathol;
Gene,RECK;
MMP-9;
Gene Expression
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression level of RECK-mRNA and MMP-9-mRNA in breast cancer(BC) and fibroadenoma tissues and its significance.Methods The mRNA level of tissues of 39 cases of breast cancer and 14 cases of fibroadenoma was measured by RT-PCR technique and its correlation was analyzed.Results The mRNA level of RECK gene in breast cancer tissues was markedly lower than that in fibroadenoma tissues,while the MMP-9 level was higher in BC tissues.Conclusions RECK is a tumor suppressor gene, the expression in benign and malignant breast tissues is a negative relationship.BECK can inhibit the expression of MMP-9 and thus,inhibit the growth and metastasis of breast cancer.
