Optimization of the Formula of Puerarin Derivative Nanoparticles by Central Composite Design
- VernacularTitle:中心复合设计法优化葛根素衍生物纳米粒处方工艺
- Author:
Xijing LIU
;
Dajian YANG
- Publication Type:Journal Article
- Keywords:
Puerarin;
4 ac;
Central composite design;
Nanoparticle;
PLGA;
PVA
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the formula technology of puerarin derivative 4ac-loaded nanoparticles by central composite design. METHODS:4ac nanoparticles were prepared using solvent evaporation method, with mean diameter, encapsulation rate and yield as dependent variables, multi-linear regression and binomial fit were performed on the 3 independent variables at different level:dosages of supporter lactic acid/ glycolic acid copolymer and surfactant polyvinyl alcohol, and the diameter of pinhole. The optimum experimental conditions were predicted by response surface method. RESULTS:The binomial fitting equations of indexes were all superior to their multi-linear regression equations, and the predictive values in the established mathematical model were in good conformity with the experimental values. CONCLUSION:Central composite design plus response surface method shows a good predictability in optimizing the formula technology of 4ac-loaded nanoparticles.
