Radiation enhancement and induced apoptosis in nasopharyngeal carcinoma cells by Arsenic Trioxide in vitro
- VernacularTitle:三氧化二砷对人鼻咽癌细胞放射增敏作用的体内实验研究
- Author:
Yajie LIU
;
Shubin WANG
;
Yueran HU
;
Dong WU
;
Maosheng YAN
;
Dong YANG
;
Xianming LI
- Publication Type:Journal Article
- Keywords:
Arsenic Trioxide;
Apoptosis;
Nasopharyngeal carcinoma
- From:
Journal of Chinese Physician
2002;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Arsenic Trioxide(As_2O_3) combined with radiation on the apoptosis of nasopharyngeal carcinoma cells in vitro.Methods Using MTT and FCM to detect the cytotoxic and apoptosis at different As_2O_3 concentrations combined with 2Gy radiation on nasopharyngeal carcinoma cells(CNE1).Results Inhibition of cell proliferation seemed more dependent on the increase of As_2O_3 concentration.Cell survival rate was lower in the combination of As_2O_3 and radiation group than As_2O_3 alone.Conclusion As_2O_3 can enhance radiation effect obviously in nasopharyngeal carcinoma cells,especially at lower radiation dose.
