Impact of remote postconditioning on rabbit hearts with acute myocardial ischemia-reperfusion injury
- VernacularTitle:肢体缺血后处理对兔急性心肌缺血再灌注损伤的影响
- Author:
Chunmei LI
;
Xinghua ZHANG
;
Xiaojing MA
;
Man LUO
;
Xujie LIU
;
Guodong WANG
- Publication Type:Journal Article
- Keywords:
Ischemic postconditioning;
Reperfusion injury;
Reactive oxygen species
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: In this study,we tested the hypothesis that remote postconditioning induced by a single 5-min episode of femoral artery occlusion and reperfusion applied immediately before the onset of coronary artery reperfusion protects the myocardium from reperfusion injury.METHODS: Thirty healthy New Zealand white rabbits were randomly divided into three groups(n=10 in each group): control,myocardial ischemic postconditioning(MIP) and Limb ischemic postconditioning(LIP).Myocardial infarct size and tissue myeloperoxidase(MPO) activity were determined at the end of the experiment.Plasma creatine kinase(CK) activity and malondialdehyde(MDA) levels were measured at baseline,the end of ischemia,and after 180 min of reperfusion,respectively.RESULTS: Myocardial infarct size was significantly reduced in MIP and LIP as compared to control(P
