HIPK2 gene expression and its clinical significance in acute leukemia
- VernacularTitle:急性白血病患者同源结构域相互作用蛋白激酶2的表达及其临床意义
- Author:
Haiyan XING
;
Xinwei ZHANG
;
Zheng TIAN
;
Kejing TANG
;
Yingchang BI
;
Min WANG
- Publication Type:Journal Article
- Keywords:
Leukemia;
Genes,HIPK2;
Gene expression
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate homeodomain-interacting protein kinase 2(HIPK2) gene expression level and its clinical significance in acute leukemia(AL) patients.METHODS: HIPK2 mRNA was determined by semi-quantitative reverse transcriptase polymerase chain reaction(semi-quantitive RT-PCR) in patients with acute leukemia and healthy donors.The relative transcription level was compared between the study group and the control group.RESULTS: ① The relative expression level of HIPK2 mRNA in AL patients was 0.364?0.286,significantly lower than that in control(1.160?0.272,P0.05).CONCLUSION: AL has significantly lower HIPK2 mRNA expression as compared to normal control,which may be associated with leukemogenesis and/or disease progression of AL.
