Prognostic prediction of PTEN and Her-2 expression in breast cancer
- VernacularTitle:PTEN和Her-2表达与乳腺癌长期预后的关系
- Author:
Lifeng SUN
;
Kefeng DING
;
Xuehua WU
;
Jiaping PENG
;
Suzhan ZHANG
;
Shu ZHENG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Prognosis;
Genes,PTEN;
Genes,Her-2
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the prognositic value of PTEN and Her-2 expression in primary breast cancer.METHODS: 81 breast cancer specimens with 15 years follow-up were obtained from 1989 to 2004.Immunohistochemical methods were used to detect the expression of PTEN and Her-2 in 81 paraffin-embedded specimens.The correlation between expression of PTEN and clinipathological factors was discussed with the Chi-square test.The survival rate analysis results were calculated with Kaplan-meier method.Long-rank test and Cox model by SPSS 10.0 software.RESULTS:(1) PTEN expression significantly affects 5-year and 10-year survival rate of breast cancer(P
