Hepatocyte protection of ethyl pyruvate in septic mice
- VernacularTitle:丙酮酸乙酯对脓毒症小鼠肝细胞的保护作用
- Author:
Minying CHEN
;
Qi ZHOU
;
Lijian LIANG
;
Baogang PENG
;
Xiangdong GUAN
;
Bin OUYANG
;
Juan CHEN
- Publication Type:Journal Article
- Keywords:
Sepsis;
Hepatocytes;
Ethyl pyruvate
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effect of ethyl pyruvate(EP) on hepatocytes in septic mice.METHODS: The cecal ligation-perforation was made in mice as septic model.Ringer's ethyl pyruvate solution(REPS) and Ringer's lactic solution(RLS) were used to resuscitate septic mice.Anti-oxidative capacity of hepatic tissue and liver function were detected in different groups.RESULTS: Anti-oxidative capacity in septic mice was significantly lower than that in sham group(P
