The effect of recombinant human growth hormone on the expression of tumor necrosis factor in the rat model of obstructive jaundice
- VernacularTitle:生长激素对实验性梗阻性黄疸时肿瘤坏死因子?的影响
- Author:
Jun SONG
;
Jingang LIU
;
Yong WANG
;
Yun YU
- Publication Type:Journal Article
- Keywords:
Growth hormone;
Jaundice,obstructive;
Tumor necrosis factor-alpha
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of recombinant human growth hormone(rhgh) on the expressions of tumor necrosis factor a(TNFa) and endotoxemia in murine experimental obstructive jaundice(OJ) models.Methods Sixty adult male wistar rats.were randomly divided into three groups A: sham operation group(SO),20;B:OJ group,20;C: OJ+rhGH group,20.The rats in group OJ and OJ+rhGH suffered from bile duct ligation,while the SO group did not.Two weeks later,rats in OJ+rhGH group were injected with rhGH subcutaneously once a day.The dose was 0.75 Iu/kg.The other two groups were injected with the same amount of saline.The endotoxin(ETX),the liver function and TNFa were detected four weeks later.Result The level of ETX(0.036?0.010EU/m1) and TNFa(182.00?88.37lpg/ml) in OJ+rhGH were much lower than those in OJ group(0.065?0.011EU/m1 P
