Analysis of the expressions of p27 and PCNA and cell apoptosis in ulcerative colitis and colon cancer
- VernacularTitle:溃疡性结肠炎与结肠癌肠黏膜中p27蛋白和PCNA的表达及凋亡的分析
- Author:
Xuehong WANG
;
Fanggen LU
;
Jirong HUO
;
Xiaoping WU
;
Limao LIN
- Publication Type:Journal Article
- Keywords:
Colitis,ulcerative;
Colonic neoplasms;
Proliferating cell nuclear antigen;
Apoptosis
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expressions of p27 and PCNA and cell apoptosis in ulcerative colitis and colon cancer.Methods The expressions of p27 and proliferation cell nuclear antigen(PCNA)proteins in colorectal cancer,ulcerative colitis and normal colon were analyzed by StrptAvidin-Biotin Enzyme Complex immunohistochemical methods.The apoptosis was detected using terminal uridine deoxynucleiotide nick end labeling(TUNEL) histochemistry.Results The level of PCNA expression in colorectal cancer and ulcerative colitis was markedly higher than that in normal colon(P
