Expressions of ?-smooth muscle actin and collagen type Ⅰ,Ⅲ in biopsy liver tissue from patients with fibrosing cholestatic hepatitis
- VernacularTitle:纤维化淤胆性肝炎肝组织?-SMA及Ⅰ、Ⅲ型胶原的表达
- Author:
Xingfeng REN
;
Xiaokun WANG
;
Qun YANG
;
Jingan LI
;
Jing YU
;
Zhigang ZHAO
;
Putao ZHAO
;
Ya GE
;
Ying TANG
- Publication Type:Journal Article
- Keywords:
Fibrosing cholestatic hepatitis;
Hepatic stellate cell;
Collagen typeⅠ;
Collagen type Ⅲ
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe expressions of ?-smooth muscle actin(?-SMA) and collagen type Ⅰ,Ⅲ deposition in the liver tissues, and to evaluate potential mechanism of fibrosis in patients with fibrosing cholestatic hepatitis (FCH) by collagen synthesis. Method Immunohistochemical staining was used to detect the expressions of ?-SMA and contents of type Ⅰ,Ⅲ collagen proteins, which were from the specimens of the biopsy liver in 9 cases with FCH associated with hepatitis virus B (HBV) developed following renal transplantation and in 5 cases without liver disease(control group), respectively. Results The expressions of ?-SMA and type Ⅰ,Ⅲ collagen proteins in the patients with FCH were significantly higher than those in the control group. The expression and distribution pattern of ?-SMA and type Ⅰ,Ⅲ collagen proteins were almost identical, and quantitative analysis showed a positive correlation (P
