Effects of safflower injection(红花注射液) on the levels of blood endothelin and nitric oxide after femoral arteriovenous fistula operation in rabbits
- VernacularTitle:红花注射液对家兔动静脉内瘘术后血中内皮素及一氧化氮水平的影响
- Author:
Yufeng JIANG
;
Liqun HE
;
Peicheng SHEN
- Publication Type:Journal Article
- Keywords:
safflower injection;
arteriovenous fistula;
endothelin;
nitric oxide
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the mechanism of safflower injection(红花注射液) on preventing thrombosis after arteriovenous fistula operation in rabbits.Method: Twenty-four rabbits were randomly divided into three groups: safflower injection group,heparin group and control group(each n=8).Rabbit femoral arteryvein side-to-side anastomosis models were performed on both sides of the lower extremities and they were coincided.Safflower injection(5 mg/kg) or heparin injection(6 U/kg) was given from ear edge vein immediately after operation in the respective group,while normal saline(0.9%) was given with the same fashion in the control group,once per day for 14 days.On the 1 st,3 rd,7 th and 15 th day after operation,the nitric oxide(NO) in serum and endothelin(ET) in plasma were determined respectively.Results: The plasma ET contents were significantly lowered in safflower and heparin groups compared with that of control group(both P
