Effects of permissive hypercapnia on inhibiting inflammatory mediators into plasma in respiratory distress syndrome of neonates
- VernacularTitle:允许性高碳酸血症对新生儿呼吸窘迫综合征外周血炎症介质的影响
- Author:
Xiufang YANG
;
Kaijun ZHENG
;
Ronghua XIA
;
Jingguo CHEN
;
Jian CHEN
;
Huijuan HUANG
- Publication Type:Journal Article
- Keywords:
Permissive hypercapnia;
Infant newborn;
Respiratory distress syndrome;
Inflammatory mediator
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(33):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes in inflammatory mediators in plasma in respiratory distress syndrome(RDS) of neonates received lung protective ventilation treatment. Methods Sixty newborn infants,diagnosed as RDS of neonatal and needed ventilator support, were recruited from the intensive care unit from May 2003 to May 2006. Infant with RDS were randomly divided into two groups. Both had 30 newborn infants. The infants in the experimental groups received lung protective ventilation treatment tidal volume:5-8 ml/kg,positive end-expiratory pressure (PEEP):0.51~0.98 kPa, and the control groups received large tidal volume ventilation (tidal volume:10-15 ml/kg,PEEP:0-0.29 kPa). The contents of TNF-?, interleukin-6 in plasma were measured. Results After those two therapies, the contents of tumor necrosis factor-?(TNF-?), interleukin-6 in plasma decreased obviously, especially after receiving lung protective ventilation treatment. Conclusions There are statistical differences in the amount of inflammatory mediators released between the experimental group under lung protective ventilation treatment and the control group received large tidal volume ventilation,and better effects are seen in RDS infants under lung protective ventilation treatment .
