The role of multi-drug resistance related proteins in hepatocellular carcinoma multidrug resistance cell line HePG2/ADM
- VernacularTitle:多药耐药相关蛋白在肝癌多药耐药细胞系HePG2／ADM中的作用
- Author:
Gaopeng LI
;
Xiaoping CHEN
;
Qi WANG
;
Zongquan XU
;
Wanguang ZHANG
;
Lu YE
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Mullidrug resistance-associated proteins;
Antineoplastic combined chemotherapy protocols
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
0. 05). At the protein level, the expressions of MDR1, BCRP and LRP in HePG2/ADM were significantly higher than HePG2 and L02 ( FMDR1= 28. 68, FBCRP= 18. 60, FLRP= 6. 28, P 0. 05). Conclusion The four genes are probably the normally expressed genes in the liver. The expression of MDR1 and BCRP could be up-regulated by anticancer agents in vitro. MDR1 and BCRP may play very important roles in the MDR of HePG2/ADM. However, MRP1 and LRP may have no relations with the multi-drug resistance of HePG2/ ADM cell lines.
