Effects of Batroxobin on intimal proliferation of graft veins
- VernacularTitle:巴曲酶对自体静脉移植内膜增生的影响
- Author:
Jian WANG
;
Fan ZHOU
;
Yan ZHOU
;
Cheng CHEN
;
Fangjie ZHANG
- Publication Type:Journal Article
- Keywords:
Transplantation, autologous;
Veins;
Batroxobin;
Intimal proliferation;
Genes
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Batroxobin( BX) on the intimal proliferation of graft veins. Methods In this study 25 dogs were selected and evenly divided into experimental group, control group and sham operation group. In experiment and control group, a segment of auto- femoral vein were grafted into femoral artery by clean microsurgery technique. In experimental group, BX was given at the dosage of 0. 1 BU/kg, dayly?2 preoperatively, and once a day for consecutive 6 days postoperatively. Plasma NO, ET was determined in the three groups. Computer image analysis system was applied to calculate the thickness of neointima and media in the vein grafts, immunohistochemistry was used to identify PCNA and C-myc. Result The experimental group had a higher level of NO and lower level of ET compared with control group and sham operation group(P 0. 05 ). The PCNA expression in experimental group was statistically different from that of the control group(P
