Relationship between expression of COX-2 and clinicopathological features in esophageal carcinoma
- VernacularTitle:食管癌中COX-2表达与其临床病理特征及预后的关系
- Author:
Zhong YU
;
Yuhong YUAN
;
Jun ZHAN
;
Jinxin ZHANG
;
Jun JIANG
- Publication Type:Journal Article
- Keywords:
Cycloxygenase-2;
Esophageal neoplasms;
Prognosis;
Protein,COX-2
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To examine COX-2 expression in esophageal carcinoma,and to study relationships between COX-2 expression and clinicopathological features and prognosis of esophageal carcinoma patients.METHODS: 89 paraffin-embedded tissue samples from patients with esophageal carcinoma were collected,its clinicopathological features such as tumour differentiation,depth of invasion,length and site of the tumor,regional lymph node metastases,distant metastasis were recorded.Survival time of 81 cases were also recorded.By SP immunohistochemistry method,the expression of COX-2 in tumor samples was examined.RESULTS: COX-2 expression in esophageal carcinoma was markedly higher than that in nomal esophagus,the expression was higher in less differentiated and deeper invaded cases(P0.05).Cases of esophageal carcinoma with lower COX-2 expression had longer survival time than those with higher COX-2 expression(P
