Effects of Kunzao Tiaozhi Capsule on Cell Proliferation in Experimental Rats with Fatty Liver and Hyperlipidemia
- VernacularTitle:昆藻调脂胶囊对实验性高脂血症性脂肪肝大鼠肝细胞增殖的影响
- Author:
Xianglian KONG
;
Quanxi MEI
;
Xiwen ZHONG
;
Yuqiao GAO
;
Hui LIN
;
Huifei WU
- Publication Type:Journal Article
- Keywords:
Kunzao tiaozhi capsule;
Hyperlipidemia;
Fatty liver;
Rat;
Cell multiplication;
Flow cytometry
- From:
China Pharmacy
2005;0(21):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the action mechanism of kunzao tiaozhi capsule in the treatment of fatty liver with hyperlipidemia.METHODS: A total of 59 rats were randomly divided into normal control group(n=10),model group(n=11),positive control group(n=10) and kunzao tiaozhi capsule group(at high,medium and low doses,n=9,9,10).Rat model with fatty livers was established in all the groups except the normal control group by feeding high-fat forage and 30% alcohol,and the corresponding solvents or medicine were given during the modeling,10 weeks later,the S-phase cell percentages(SPF) of the liver cells in rats and proliferation index(PI) were determined by flow cytometry methods.RESULTS: As compared with the normal control group,PI and SPF values in the modeled rats increased significantly(P
