Experimental study of kansui root and LMWH combined therapy for severe acute pancreatitis
- VernacularTitle:甘遂和低分子量肝素联合应用治疗重症急性胰腺炎的实验研究
- Author:
Xiaoji PAN
;
Xinsheng LU
;
Lian DUAN
;
Shanzheng CHEN
;
Xuequn REN
;
Jianyun CHEN
;
Yixiong LI
- Publication Type:Journal Article
- Keywords:
Panereatitis/drug ther;
Kansui/ther use;
Herarrain,Low Molecular Weight/ther use
- From:
Chinese Journal of General Surgery
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate if there is a synergism of kansui root and low molecular weight heparin(LMWH) in combined treatment of SAP in rats.Methods SD rats were randomly divided into 5 groups:Sham group(A group),severe acute pancreatitis group(B group),kansui root treatment group(C group),LMWH treatment group(D group),combined treatment group(E group).The serum TNF-?,IL-6 level and the ratio of TXB2/6-keto-PGF1? in pancreatic tissue,and the histological examination were evaluated.Results The values of TNF-??IL-6 and the ratio of TXB2/6-keto-PGF1? in C,D,E group were significantly lower than those in B group at the time point of 6,12,24h.But there were no significant differences in C,D,E group at all the time points.The histological examination showed that the pancreas was normal in group A;the pathological changes were milder in C,D,E group than that in B group.Conclusions Combined treatment of kansui root and LMWH was effective in SAP,but there was no synergism,and also no side effects.
