Down-regulation of TGF?receptor expression in human basal cell carcinoma and squamous cell carcinoma
- VernacularTitle:基底细胞癌和鳞状细胞癌中转化生长因子?Ⅰ型和Ⅱ型受体表达
- Author:
Ying LI
;
Wei HE
;
Guofu YAN
;
Yunzhi HE
;
Hai HUANG
;
Lei YAO
;
Zihua LIN
;
Jun WU
- Publication Type:Journal Article
- Keywords:
Carcinoma, basal cell;
Carcinoma, squamous cell;
Transforming growth factor beta;
Receptors, transforming growth factor beta
- From:
Chinese Journal of Dermatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of transforming growth factor beta receptors (TGF?RⅠ, TGF?RⅡ) in basal cell carcinoma and squamous cell carcinoma. Methods The expression of TGF?RⅠand TGF?RⅡwere assessed by quantitative real-time PCR and streptavidin -peroxidase (SP) immunohistochemical techniques in specimens of basal cell carcinoma, squamous cell carcinoma and normal control skin. Results Eighteen patients with basal cell carcinoma and twenty-four with squamous cell carcinoma were enrolled in the study. The expression levels of TGF?RⅠand RⅡmRNA were significantly down-regulated in basal cell carcinoma and squamous cell carcinoma in comparison with those in control skin specimens (P
