The genetic polymorphisms of DC-SIGN and DC-SIGNR among female sex workers
- VernacularTitle:暗娼人群DC-SIGN及DC-SIGNR基因多态性初步研究
- Author:
Feng WANG
;
Fuchang HONG
;
Hui WANG
;
Lina LAN
;
Wang CHUNHUI
;
Likuan XIONG
;
Xin XIAO
;
Boping ZHOU
;
Hua ZHOU
;
Zhu TUOFU
- Publication Type:Journal Article
- Keywords:
DC-SIGN;
DC-SIGNR;
Polymorphism, genetic;
Female sex worker
- From:
Chinese Journal of Dermatology
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the genetic polymorphisms of DC-SIGN and DC-SIGNR among HIV negative Chinese female sex workers. Methods The 69 bp tandem repeat numbers in exon 4 of the DC-SIGN and DC-SIGNR were examined by PCR in 234 HIV-1-seronegative female commercial sex workers. Results It was found that 4 of 234 individuals were heterozygous in DC-SIGN. For DC-SIGNR, the allele frequencies were seven times repeated in 65.2%, 5 in 18.4%, and 9 in 11.9%. Those patterns of alleles frequencies were significantly different compared with those reported in the Caucasians residing in Europe. Conclusion Polymorphisms of DC-SIGN repeat region seem to be infrequent in Chinese female sex workers and those of DC-SIGNR are different from what reported in other races.
