Analysis of the autoantibodies against ?_1 and ?_1-adrenergic receptor in patients of hypertension with renal failure
- VernacularTitle:抗?_1和?_1肾上腺素能受体自身抗体与高血压合并肾损害关系的临床研究
- Author:
Linshuang ZHAO
;
Yuhua LIAO
;
Min WANG
;
Zihua ZHOU
;
Guangda XIANG
;
Lin YU
;
Lin XU
;
Hongyan CAO
- Publication Type:Journal Article
- Keywords:
Receptors,adrenergic,alpha 1;
Adrenergic alphaantagonists;
Receptors,adrenergic,beta 1;
Adrenergic beta-antagonists;
Endothelins;
Autoantibodies;
Hypertension/ complications;
Kidney diseases/etiology
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of the autoantibodies against ?_1 and ?_1-adrenergic receptor(?_1-receptor)in the development of hypertension with renal failure.Methods The epitopes of the second extracellular loop of ?_1-receptor(197-222) and ?_1-receptor(192-218) were synthesized and used respectively to screen sera autoantibodies in patients with hypertension and renal failure(n=61),hypertension without renal failure(n=60) and healthy blood donors(n=40,control) by ELISA.Results The positive rates of the autoantibodies against ?_1-receptor(62.3%)and ?_1 receptor(50.8%) in patients with hypertension with renal failure were higher than those of patients with hypertension without renal failure(13.3% and10.0%)(P
