High-dose chemotherapy in patients with terminal malignant tumors supported by autologous peripheral blood stem cells transplantation
- VernacularTitle:自体外周血干细胞移植支持下大剂量化疗治疗晚期恶性肿瘤的研究
- Author:
Xinfu ZHOU
;
Xiaochuan CHEN
;
Wenyong KUANG
;
Sang FU
;
Menglun CHEN
;
Lihua LIU
;
Yuxia LIU
;
Shaofang CHEN
- Publication Type:Journal Article
- Keywords:
Peripheral blood stem cell transplantation;
Drug therapy;
Neoplasms
- From:
Journal of Chinese Physician
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the safety and effectiveness of high-dose chemotherapy(HDT) supported by autologous peripheral blood hematopoietic stem cells transplantation(APBHSCT) in the patients of terminal or relapsed malignant tumors.Methods The patients achieved CR or PR after 4 cycles of conventional salvage chemotherapy were divided into two groups randomly.26 patients in the research group were adapted APBHSC+HDC,50 patients in the control group were adapted 2～4 cycles of routine chemotherapy.Results In the research group,hematopoiesis was reconstructed in all patients,8 out of 17 patients who achieved PR after 4 cycles of conventional salvage chemotherapy turned into CR after APBHSC+HDC(CR rate 47.1%).In the control group,33 patients who achieved PR after 4 cycles of conventional salvage chemotherapy were still PR after 2～4 cycles of routine chemotherapy.The median survival period in the research group was 11 months,which was longer than the one in the control group.The survival rates of 2,3 and 4 years in the research group were evidently higher than the ones in the control group(P
