Effect of Liposome-encapsulated Bisdemethoxycurcumin on the Proliferation of Human Lung Adenocarcinoma Cell Line A549
- VernacularTitle:双脱甲氧基姜黄素脂质体对体外培养人肺腺癌A549细胞增殖活性的影响研究
- Author:
Liang GONG
;
Heping YANG
;
Jianming LI
;
Xiangdong ZHOU
- Publication Type:Journal Article
- Keywords:
Bisdemethoxycurcumin liposome;
Adenocarcinoma of lung;
Cell line A549;
Proliferation
- From:
China Pharmacy
2005;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of liposome-encapsulated demethoxycurcumin on the proliferation of human lung adenocarcinoma cell line A549.METHODS:The in vitro cultured human lung adenocarcinoma cell line A549 was treated with liposome-encapsulated Bisdemethoxycurcumin.The bionomics including morphology and cell cycle of cell line A549 were observed by morphological analysis,MTT assay and flow cytometry assay.RESULTS:Marked morphological changes were noted in cell line A549 under microscope.Liposome-encapsulated Bisdemethoxycurcumin showed inhibitory action on the growth of A549 cell lines,with IC50 at 12.108?g/mL.The progression of cell cycle was arrested in S phase.CONCLUSION:Liposome-encapsulated Bisdemethoxycurcumin can inhibit the growth of human lung adenocarcinoma cell line A549,which has a promising future in the treatment of adenocarcinoma of lung.
