Preparation of Oleanolic Acid Loaded Polybutylcyanoacrylate Nanocapsules by Interfacial Polymerization
- VernacularTitle:界面聚合法制备齐墩果酸聚氰基丙烯酸正丁酯纳米囊及其质量考察
- Author:
Jing XIAO
;
Xinzhong LI
;
Shao LIU
;
Peng LEI
- Publication Type:Journal Article
- Keywords:
Interfacial polymerization;
Oleanolic acid;
Polybutylcyanoacrylate;
Nanocapsules;
Orthogonal experiment
- From:
China Pharmacy
2005;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the formula and preparation technique of oleanolic acid loaded polybutylcyanoacrylate nanocapsules(OA-PBCA-NC)by interfacial polymerization and to study its quality.METHODS:The preparation technique of OA-PBCA-NC prepared by interfacial polymerization were optimized by single factor design,and the formula was optimized by orthogonal design with entrapment ratio as index.Its shape,particle size and the entrapment ratio were investigated as well.RESULTS:The optimized dosage ratios were as follows∶ OA vs.BCA∶60mg∶0.1ml;acetic ether vs.BCA∶2.0ml∶0.1ml;and oil vs.water:1∶1.The prepared nanocapsules were round and regular in shape without adherence.The particle size was well-distributed with mean diameter at(214?8)nm and mean entrapment ratio at(76.8?0.4)%.CONCLUSION:The preparation technique of OA-PBCA-NC established in this study is stable and feasible.
