Determination of 5-FU in Serum,Peritoneal Fluid and Tissue by HPLC in Patients Undergoing Rectal Cancer Operation and Receiving Regional Chemotherapy
- VernacularTitle:高效液相色谱法测定直肠癌术中区域化疗血液、盆腔液和组织5-氟尿嘧啶浓度
- Author:
Jiang DU
;
Chongshu WANG
;
Xiang ZHANG
;
Bin YUAN
- Publication Type:Journal Article
- Keywords:
Rectal cancer;
Regional chemotherapy;
5-FU;
HPLC
- From:
China Pharmacy
2005;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine 5-Fu concentration in serum,peritoneal fluid and tissue by HPLC in patients undergoing rectal cancer operation and receiving regional chemotherapy.METHODS:20 patients who undergoing rectal cancer operation and receiving regional chemotherapy were administered with drugs,whose blood samples were taken from portal veins,peripheral veins,peritoneal fluid and tissues around tumor at 2,5,10,20,30 and 60min,respectively after administration for the determination of 5-FU by HPLC.RESULTS:Peak concentrations in all samples appeared 2 minutes after administration,but lowered gradually thereafter.The drug level in peritoneal fluid was the highest,but was the lowest in the tissue,and that in the portal vein was higher than in peripheral veins.CONCLUSION:For patients who undergoing rectal cancer operation,regional chemotherapy could maintain 5-FU concentration at a higher level in portal vein,peritoneal fluid and tissue around cancer,which has significance in the prevention of metastasis to the local sites and liver after rectal cancer operation.
