Clinical significance of molecular markers and routine coagulation tests in patients with cerebral infarction
- VernacularTitle:脑梗死患者血浆中血栓标志物及凝血指标联合检测的临床意义
- Author:
Mei HUO
;
Yong XU
;
Lin HE
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Thrombin;
Prothrombin;
Biological markers;
Antithrombins
- From:
International Journal of Laboratory Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance of molecular markers and routine coagulation tests in patients with cerebral infarction and to set up a serial programs of laboratory diagnosis,monitoring and treatment of cerebral infarction.Methods Prothrombin fragment 1+2(F1+2),thrombin antithrombin III complex(TAT), D-dimer(D-D),Von willebrand Factor(vWF),antithrombin(AT), protein C(PC),prothrombin time(PT),activated partial thromboplastin time(APTT) and thrombin time (TT) were determined in 90 patients with cerebral infarction and 60 normal control subjects.Results The levels of F1+2,TAT,D-D,vWF were significantly higher in patients with cerebral infarction than that in control subjects. But the levels of PC,AT,PT,APTT,TT in patients with cerebral infarction were no different from that in control subjects.Conclusion There were hypercoagulable states in patients with cerebral infarction.The activity of prothrombin is higher, thrombin is generated more, the activity of fibrinolysis is higher too, but anticoagulation system is not sufficiently activated .Meanwhile, perhaps endothelial lesion would be the main role of coagulation system activating and pathogenesis.Molecular markers such as F1+2,TAT,D-D,VWF can be as diagnositic signs but routine coagulable tests can not display the hypercoagulable states in patients with cerebral infarction.
