Effect of 17?-estrodiol on portal hypertensive gastropathy of rats
- VernacularTitle:雌激素对大鼠门静脉高压性胃病的影响及其机制
- Author:
Yuewu LIU
;
Weisheng GAO
;
Xiaoyi LI
;
Hongfeng LIU
;
Xiaoyu CUI
- Publication Type:Journal Article
- Keywords:
Hypertension, portal;
Gastropathy;
Estrogens;
Nitric oxide
- From:
Chinese Journal of General Surgery
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify if estrogen increases gastric mucosal injury in portal hypertensive rats and its role in the pathogenesis of portal hypertensive gastropathy. Methods Forty SD rats were divided into 4 groups:P + E, P, S + E and S groups. P + E and P groups received portal vein ligation and the S + E and S groups underwent sham operation. P + E and S + E groups were given estrogen intramascularly. All rats were maintained on their indiuidual treatment for 14 days. One hour before the sacrifice rats were orally lavaged with 2 ml 99% ethanol. Gastric mucosal blood flow, degree of gastric mucosal injury and mucosal NO production were determined. Results The P + E group had the highest gastric blood flow of (103?14) U compared with the other 3 groups (P
