Study on Growth Effect and Apoptosis Action of Quercetin on Human Gastric Carcinoma Cells MGC-803
- VernacularTitle:槲皮素对胃癌MGC-803细胞生长及凋亡作用的研究
- Author:
Haiyan WANG
;
Liangmiao GUO
;
Yong CHEN
;
Xuehua ZHAO
;
Cailian CHENG
;
Mianyun WU
;
Liya HE
- Publication Type:Journal Article
- Keywords:
Quercetin;
MGC-803 cells;
Proliferation;
Inhibitory effect;
Apoptosis
- From:
China Pharmacy
2005;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of quercetin on the proliferation and apoptosis of human gastric carcinoma cell line MGC-803.METHODS:MTT assay was adopted to measure the effect of quercetin at different concentrations on the proliferation of MGC-803 cells.Cell apoptosis index(AI)induced by quercetin was measured by TUNEL assay.RESULTS: Quercetin at a certain concentration from 40?mol/L to 100?mol/L could successfully inhibit the proliferation of MGC-803 cells in a dose-dependent manner.TUNEL assay indicated that apoptosis cells induced by quercetin in treatment group were much more than that in control group after 48 hours(P
