Effects of 5-HT and electrolytes on the airway remodeling of bronchial asthma in guinea pigs
- VernacularTitle:5-羟色胺与电解质在支气管哮喘豚鼠气道重塑中的作用
- Author:
Baosheng CHEN
;
Shengyuan LIU
;
Xianghong WANG
;
Shangbin YU
;
Qiling CHEN
;
Shiqiao YE
- Publication Type:Journal Article
- Keywords:
Serotonin;
Electrolytes;
Airway remodeling;
Asthma;
Guinea pig
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effects of 5-HT and electrolytes on the airway remodeling in guinea pigs with bronchial asthma.METHODS: 70 guinea pigs were divided into 7 groups: control group,model group,continued model group,5-HT group,anti-5-HT group,high Mg~(2+) group,low Mg~(2+) group.Remodeling model was established with ovalbumin.RESULTS: ① In model group,5-HT of serum and thickness of airway walls were significantly increased compared with control group(P
