Significance of expression of extracellular matrix metalloproteinase inducer and endothelin converting enzymes in lymphoid metastasis and prognosis in non-small-cell lung carcinoma
- VernacularTitle:细胞外基质金属蛋白酶诱导因子和内皮素转化酶对非小细胞肺癌患者术后淋巴结转移和预后的影响
- Author:
Huizhong ZHANG
;
Haigang LI
;
Yiping WEI
;
Jingeng LIU
;
Deng WU
;
Yongke CAO
;
Mei WANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Immunohistochemistry;
Extracellular matrix metalloproteinase inducer;
Endothelin converting enzymes;
Lymphatic metastasis;
Prognosis
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of extracellular matrix metalloproteinase inducer(EMMPRIN) and endothelin converting enzymes(ECE) in non-small-cell lung carcinoma(NSCLC),and their relationship with lymphoid metastasis and prognosis.METHODS: Expression of EMMPRIN and ECE in 77 cases of patients with NSCLC was detected immunohistochemically.The relationship of the expression of EMMPRIN and ECE with tumor size,histological type,differentiation,lymphoid metastasis,clinical stage,and prognosis were analyzed.RESULTS: The expressive rate of EMMPRIN and ECE was 66% and 45%, respectively.The expression of EMMPRIN and ECE was associated positively with lymphoid metastasis(both P0.05).The expression of EMMPRIN was associated with the expression of HGF in NSCLC(P
