Accelerating hematopoietic recovery in mice after allogeneic bone marrow transplantation by co-infusion of bone marrow mesenchymal stem cells
- VernacularTitle:骨髓间充质干细胞促进异基因骨髓移植后造血恢复
- Author:
Wenbing HU
;
Qingping GAO
;
Gangsheng WANG
;
Guoxin FEI
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cell;
Bone marrow cells;
Bone marrow transplantation;
Transplantation,heterologous;
Hematopoietic system
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of co transfusion of bone marrow mesenchymal stem cells(BMMSC) on hematopoietic recovery in mice after allogeneic bone marrow transplantation(allo-BMT).Methods Both BMMSC obtained after three to four weeks of culture and bone marrow cells of donor mice C57BL/6(H-2~b) were transplanted into the recipient mice BalB/c(H-2~d) that were lethally irradiated.Peripheral blood cells were counted on day 1,7,and 14 post-transplantation.CFU-S in recipient bone marrows were measured on day 7 and 14.Results The numbers of peripheral WBC,RBC,platelets and the number of CFU-S in recipient bone marrows on day 7 and 14 were all significantly higher in the co-infusion group than those in control group(P
