The increase of plasma adrenomedullin and endothelin levels in patients with serious injuries complicated by hemorrhagic shock
- VernacularTitle:严重创伤合并失血性休克患者血浆肾上腺髓质素及内皮素含量的变化
- Author:
Huaman ZHOU
;
Yingnian MIAO
;
Guofen LIU
;
Wujian OU
- Publication Type:Journal Article
- Keywords:
Shock,traumatic;
Renin;
Endothelin-1
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of the plasma adrenomedullin(ADM) and endothelin(ET-1) concentrations in patients with serious injuries complicated by hemorrhagic shock.Method Plasma ADM and ET-1 concentrations were measured by radioimmunoassay in 38 hemorrhagic shock patients(A group)and 36 non-hemorrhagic shock patients(B group)among 74 serious injury patients in the early stage and 30 age-sexmatched healthy(C group) control subjects.Results Plasma ADM and ET-1 concentrations in B group and A group,including mild(A_1 group),middle(A_2 group) and serious(A_3 group) hemorrhagic shock patients were significantly higher than those of C group.The plasma ADM and ET-1levels were greatly higher in A group than in B group.Their levels in A_1,A_2 and A_3 groups were progressively increased.There were statistical differences between A_1 and A_2 group,A_1 and A_3 group,A_2 and A_3 group respectively.There were similar increases of the plasma ET-1/ADM ratio in A group,and the ratios in A_1,A_2 and A_3 group were progressively increased also.There were positive correlations between increased plasma ADM levels and the increased plasma ET-1 levels in both A group and B group patients(r=0.492,0.438,P
