Expressions of vascular endothelial growth factor and transforming growth factor-beta1 by the intima of balloon-injured rabbit carotid arteries
- VernacularTitle:血管内皮生长因子和转化生长因子?_1在兔动脉损伤后内膜中表达及意义
- Author:
Yi ZHANG
;
Yulian YANG
;
Ying GUO
;
Baiqin OU
;
Zhongping NING
;
Yangping LUO
;
Bo CUI
;
Mingqiang TANG
;
Qinhua FU
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factors;
Transforming growth factor beta;
Carotid artery injuries;
Tunica intima
- From:
Journal of Chinese Physician
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a rabbit model of restenosis and analyze the expressions of VEGFmRNA and TGF-?_1mRNA during the intimal proliferation.We also explored the relationship between VEGFmRNA,TGF-?_1mRNA and restenosis.Methods 40 healthy male New Zealand white rabbits were evenly divided into three injury groups and one control group.Right carotid arteries were injured with PCI balloon in the injury groups.10 rabbits of each injury group were sacrificed on weeks 1,2 and 4 after the injury.VEGFmRNA and TGF-?_1mRNA were examined by in situ hybridization.All the samples were analyzed using a computerized imaging analysis system.Results In the injury groups,neointimal areas were significantly larger than those in control group(P
