Expression of telomerase inhibitor Pinx1 in leukemia cells and its correlation with telomerase activity
- VernacularTitle:白血病细胞中端粒酶抑制因子Pinx1的表达与端粒酶活性关系的研究
- Author:
Jie SUN
;
Yamin TAN
;
He HUANG
;
Yuanyuan ZHU
;
Jianping LAN
;
Xiaoyu LAI
- Publication Type:Journal Article
- Keywords:
Pinx1;
Leukemia;
Telomerase
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the expression of telomerase inhibitor Pinx1 in acute leukemia cells and during the differentiation of acute promyelocytic leukemia cells, and to realize its effect on telomerase activity. METHODS: Realtime quantitative PCR with fluorescence probe hybridization was used to measure the expression of Pinx1 and hTERT mRNA in acute leukemia cells and during differentiation of NB4 cells induced by ATRA. The correlations between Pinx1 and hTERT expression were also analyzed. RESULTS: Pinx1 mRNA expression in acute leukemia samples (0.00312, 5.42?10 -4-0.024) was significantly higher than that in normal bone marrow mononuclear cells (7.89?10 -4, 0-0.00863, P
