Relationship between RUNX3,cyclin E,P21 and survival in gastric cancer patients
- VernacularTitle:胃癌中RUNX3、cyclinE和P21蛋白表达与患者生存的关系
- Author:
Jinming CHEN
;
Jianxin GAN
;
Chunzhao YU
;
Shenhua WANG
;
Junsong WU
;
Jianhua YI
;
Jianxin YANG
;
Haibo ZHOU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Genes,RUNX3;
Protein p21;
Survival;
Cyclin E
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To evaluate the relationship between RUNX3,cyclin E,P21,biological features and survival in gastric cancer patients.METHODS:RUNX3 was examined using immunohistochemical staining.Cyclin E and P21 were analyzed by flow cytometry.Survival was evaluated by Kaplan-Meier survival curves.RESULTS:The positive-expression rate of RUNX3,cyclin E and P21 in tumor tissue from 56 patients with gastric cancer were 44.6%,64.3% and 32.1%,respectively.RUNX3 expression was correlated with lymph node metastasis and distant metastasis(P0.05).Using Kaplan-Meier survival curves and the Log-rank test,there was correlation between RUNX3,cyclin E and survival(P0.05).CONCLUSION:RUNX3 may be related with tumorigenesis and tumor progression by affecting P21 expression.The detection of RUNX3 and cyclin E may be helpful in evaluating the clinicopathological parameters and prognosis in gastric carcinoma patients.
