Relationship between tumor metastasis suppressor gene KAI1 and the invasive and metastatic characteristics of osteosarcoma
- VernacularTitle:转移抑制基因KAI1与骨肉瘤侵袭转移特性的关系
- Author:
Tingsheng PENG
;
Jushi QIU
;
Zhi LI
;
Huizhen LIANG
;
Yan WANG
;
Huixi WU
- Publication Type:Journal Article
- Keywords:
Osteosarcoma;
Neoplasm metastasis;
Genes,KAI1;
Neoplasm invasiveness
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To study the expression of metastasis suppressor gene KAI1 mRNA in osteosarcoma tissue and osteosarcoma cell lines,and the relationship between it and the biological behavior of the tumor cells.METHODS:RT-PCR was used to detect KAI1 mRNA in 18 cases of resected fresh osteosarcoma samples and three cultured osteosarcoma cell lines.The proliferative rate,the adhesive and invasive abilities of the 3 cell lines were detected.The results were treated by analysis system of images and analyzed with t test.RESULTS:The relative amount of KAI1 mRNA in osteosarcomas with lung metastasis was 0.80?0.50,while that was 1.48?0.64 in osteosarcomas without lung metastasis,the former was significantly lower than the latter(P
