Study of zinc element and ZnT3 mRNA expression in mouse brain
- VernacularTitle:小鼠脑中Zn元素和ZnT3mRNA表达的研究
- Author:
Yuanxun ZHANG
;
Jiangang LONG
;
Yinsong WANG
;
Delu LI
;
Fudi WANG
;
Hui SHEN
;
Aiguo LI
;
Guilin ZHANG
;
Yuying HUANG
;
Wei HE
- Publication Type:Journal Article
- Keywords:
Brain;
Zinc;
Zinc transporter;
Gene expression
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the interaction and function between ZnT3 mRNA expression and zinc elemental distribution in brain slice of mouse.METHODS:Zinc distribution was determined by SRXRF and ZnT3 mRNA expression in tissue was examined by RT-PCR method.RESULTS:Zinc content in cerebral cortex and hippocampus was significantly higher than that in other positions.The highest expression of ZnT3 mRNA was observed in cerebrum,hippocampus and testis.However,the ZnT3 mRNA was not detected in heart,liver,lung,spleen,kidney,intestine,olfactory bulb and cerebellum.CONCLUSION:ZnT3 facilitates the accumulation of zinc in synaptic vesicles and may play important roles in structuring of vesicular zinc pool.
