Effects of hypothalamic supraoptic ADH neurons at different times after hypophysectomy in Wistar rats
- VernacularTitle:Wistar大鼠垂体切除后不同时段对下丘脑视上核ADH神经元的影响
- Author:
Yihua WANG
;
Songtao QI
;
Jialin ZHANG
;
Zhirui YUAN
;
Fanghe GONG
;
Chengyong LIU
- Publication Type:Journal Article
- Keywords:
Hypophysectomy;
Diabetes insipidus,neurogenic;
Vasopressins;
Supraoptic nucleus
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the effects of supraoptic ADH neurons and central diabetes insipidus(CDI)in Wistar rats at different times after hypophysectomy.METHODS:Hypophysectomy was undergone by stereotaxic instrument.Water intake,urine output and urine specific gravity(SG)were observed each day.The survival rate of supraoptic ADH neurons was determined by immunofluorescence after hypophysectomy at different times.RESULTS:The rats manifested triphasic CDI after hypophysectomy.The average water intake in experiment group was 73.9 mL vs 30.9 mL in control group(P0.05),but the cellular body hypertrophy appeared.The survival rate at 10th day was 72%(P0.05),but they were all less than the 10th day(P
